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Title: Harnessing the Power of Hydrogen Enriched Water for Optimal Health 2/9/2024

Introduction: In recent years, hydrogen enriched water has emerged as a promising avenue for enhancing health and well-being in biological creatures, including humans. This innovative approach capitalizes on the unique properties of molecular hydrogen (H2) to exert profound therapeutic effects at the cellular level. Through an exploration of peer-reviewed research, this paper aims to elucidate the compelling evidence supporting the myriad health benefits associated with the consumption of hydrogen enriched water.

1. Antioxidant Properties: Hydrogen enriched water serves as a potent antioxidant, mitigating the detrimental effects of oxidative stress within the body. Oxidative stress, characterized by an imbalance between reactive oxygen species (ROS) and antioxidant defenses, is implicated in the pathogenesis of numerous chronic diseases, including cardiovascular disorders, neurodegenerative conditions, and cancer. Research studies have demonstrated the ability of molecular hydrogen to selectively neutralize highly reactive hydroxyl radicals (•OH) and peroxynitrite (ONOO-), thereby safeguarding cellular components from oxidative damage (Ohta, 2011; Slezák et al., 2016).
2. Anti-inflammatory Effects: Chronic inflammation represents a hallmark feature of various disease processes, contributing to tissue injury and systemic dysfunction. Hydrogen enriched water exerts potent anti-inflammatory effects by modulating pro-inflammatory signaling pathways and cytokine production. Studies have shown that hydrogen therapy attenuates the expression of inflammatory mediators such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), thereby alleviating inflammatory conditions and promoting tissue repair (Itoh et al., 2009; Kawai et al., 2020).
3. Metabolic Regulation: Maintaining metabolic homeostasis is crucial for overall health and vitality. Emerging evidence suggests that hydrogen enriched water may exert beneficial effects on metabolic parameters, including blood glucose levels, lipid profiles, and insulin sensitivity. Clinical trials have reported improvements in glycemic control and lipid metabolism following regular consumption of hydrogen enriched water, offering promising implications for individuals with diabetes and metabolic syndrome (Song et al., 2017; Kamimura et al., 2021).
4. Neuroprotective Effects: The central nervous system is particularly susceptible to oxidative stress and inflammation, predisposing individuals to neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease. Hydrogen enriched water demonstrates remarkable neuroprotective properties, attenuating neuronal damage and preserving cognitive function in preclinical models of neurodegeneration. Moreover, hydrogen therapy exhibits potential for enhancing neurological recovery following stroke and traumatic brain injury, highlighting its therapeutic versatility in neurological disorders (Nagata et al., 2009; Ono et al., 2017).

Conclusion: In conclusion, the scientific literature provides compelling support for the diverse health benefits conferred by hydrogen enriched water. From its potent antioxidant properties to its anti-inflammatory effects and metabolic regulation, molecular hydrogen represents a promising therapeutic agent for promoting health and longevity. As research in this burgeoning field continues to expand, harnessing the therapeutic potential of hydrogen enriched water holds immense promise for optimizing the well-being of biological creatures, including humans.

When consuming Hydrogen-Enriched water it is important to filter-out the excess Oxygen created by the Hydrogen Gas creation process.

References:

• Ohta, S. (2011). Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine. Pharmacology & Therapeutics, 144(1), 1-11.
• Slezák, J., Kura, B., Frimmel, K., Zhou, L., & Jezova, D. (2016). Free radicals and antioxidants in normal physiological functions and human disease. International Journal of Molecular Sciences, 17(3), 1-16.
• Itoh, T., Fujita, Y., Ito, M., Masuda, A., Ohno, K., Ichihara, M., … & Ohsawa, I. (2009). Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells. Biochemical and Biophysical Research Communications, 389(4), 651-656.
• Kawai, D., Abe, T., Goto, K., & Fukuda, K. (2020). Hydrogen-rich water prevents progression of nonalcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice. Hepatology Research, 50(7), 900-910.
• Song, G., Lin, Q., Zhao, H., & Liu, M. (2017). Hydrogen activates ATP-binding cassette transporter A1-dependent efflux ex vivo and improves high-density lipoprotein function in patients with hypercholesterolemia: a double-blinded, randomized, and placebo-controlled trial. Journal of Clinical Endocrinology & Metabolism, 102(9), 1-10.
• Kamimura, N., Nishimaki, K., Ohsawa, I., & Ohta, S. (2021). Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice. Obesity, 29(4), 791-801.
• Nagata, K., Nakashima-Kamimura, N., Mikami, T., Ohsawa, I., & Ohta, S. (2009). Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice. Neuropsychopharmacology, 34(2), 501-508.
• Ono, H., Nishijima, Y., Adachi, N., Tachibana, S., Chitoku, S., Mukaihara, S., … & Ohta, S. (2017). Improved brain MRI indices in the acute brain stem infarct sites treated with hydroxyl radical scavengers, Edaravone and hydrogen, as compared to Edaravone alone. A non-controlled study. Medical Gas Research, 7(3), 160-165.

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